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Within these diverse cell types, TRP channels participate in physiological processes ranging from sensation to skin homeostasis. In addition, there is a growing body of evidence implicating abnormal TRP channel function, as a product of excessive or deficient channel activity, in pathological skin conditions such as chronic pain and itch, dermatitis, vitiligo, alopecia, wound healing, skin carcinogenesis, and skin barrier compromise. These diverse functions, coupled with the fact that many TRP channels possess pharmacologically accessible sites, make this family of proteins appealing therapeutic targets for skin disorders. Transient Receptor Potential TRP channels constitute a large family of ion channels expressed across vertebrate and invertebrate animal species. TRP channels are widely distributed across tissues, such that every cell in the body likely expresses one or more subtypes. Furthermore, TRP channels can be gated by an astonishingly diverse array of physical and chemical stimuli, ranging from ions and small molecules to heat, cold, and mechanical force [ 1 , 2 , 3 ]. Consequently, TRP channels are important for many aspects of health and disease [ 4 ]. Functional TRP channels consist of four subunits surrounding a central channel pore. In most cases, TRP channels are homotetramers of a given subunit, while in others, subunits of two different TRP channel subtypes contribute to a heterotetrameric channel.
1. Introduction to TRP Channels
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Shocking photographs of Democrat Katie Hill posing naked with a tattoo of what appears to be a Nazi-era Iron Cross on her bikini line while smoking a bong and making out with her young female aide have been obtained exclusively by DailyMail. The congresswoman, 32, was also pictured naked brushing the young woman's hair, who DailyMail. Hill's wild lifestyle has been laid bare in a cache of texts and intimate photographs obtained by DailyMail.